Advancing a class on top of statins
World Class Leadership

Medical and Scientific Advisory Board

Dyslipidemia
John Kastelein
John Kastelein

MD, PhD, FESC

Dr. Kastelein is a Medical Advisory Board member for Gemphire. Dr. Kastelein is Professor of Medicine, Chairman of the Department of Vascular Medicine, and Strategic Chair of Genetics in Cardiovascular Disease at the Academic Medical Center of the University of Amsterdam. In 2014, he was the Robert Levy Memorial Lecturer at American Heart Association Scientific Sessions. Dr. Kastelein has published over 740 research papers and he was one of the 3000 Highly Cited Researchers in 2014.

Evan Stein
Evan A. Stein

MD, PhD, FRCPC, FCAP

Dr. Stein is a Medical Advisory Board member for Gemphire. Dr. Stein is the director of the Cholesterol Treatment Center, and Director of the Metabolic and Atherosclerosis Research Center in Cincinnati. He is also the Voluntary Professor at the Pathology and Laboratory Medicine at the University of Cincinnati Medical Center. Dr. Stein is the Managing Partner of EVLIN Consultants. He founded PPD Global Central Labs in 1988, and he was an executive officer of Medpace Reference Laboratories.

Robert Hegele
Robert Hegele

MD, FRCPC, FACP, FAHA, FCAHS

Dr. Hegele is a Medical Advisory Board member for Gemphire. Dr. Hegele is a distinguished professor and research scientist of Robarts Research Institute and director of the Blackburn Cardiovascular Genetics Lab and London Regional Genomics Centre. He has over 600 publications and he was awarded for The Journal of Lipid Research Lectureship Award, 2012 Kern Lipid Conference.

Dirk Blom
Dirk Blom

PhD

Dr. Blom is a Medical Advisory Board member for Gemphire. Dr. Blom is the head of the Division of Lipidology at the University of Cape Town, head of the Lipid Clinic at Groote Schuur Hospital, and the member of executive committee of the Lipid and Atherosclerosis Society of Southern Africa. Dr. Blom is a member of South African Medical Association and South African Heart Association.

Harold Bays
Harold Bays

MD, FTOS, FACC, FACE, FNLA

Dr. Bays is a Medical and Scientific Advisory Board member for Gemphire. He has served as an Investigator in over 400 Phase I - IV clinical trials for treatments for high cholesterol and other dyslipidemias, obesity, diabetes mellitus, hypertension, osteoporosis, and other metabolic and hormonal disorders. Dr. Bays has served as Medical Director of L-MARC Research Center since 1989, and has served as President of L-MARC Research Center since its independent incorporation in 1998.

Peter Toth
Peter Toth

MD, PhD, FAAFP, FNLA, FAHA

Dr. Toth is a Medical and Scientific Advisory Board member for Gemphire. He is a diplomate of the American Board of Family Practice and the American Board of Clinical Lipidology. Dr. Toth is a member of Alpha Omega Alpha, the American College of Cardiology Foundation Council on Cardiovascular Disease Prevention, and the American Heart Association's Council on Lipoproteins, Lipid Metabolism, and Thrombosis. Dr. Toth has authored and coauthored over two hundred twenty publications in medical and scientific journals and textbooks. He has lectured on many topics in cardiovascular medicine throughout the United States.

NASH
Jay Horton
Jay Horton

MD

Dr. Horton is a Medical and Scientific Advisory Board member for Gemphire. He is a Professor of Internal Medicine and Molecular Genetics, Chief of the Division of Digestive and Liver Diseases, and holds the Robert C. and Veronica Atkins Chair in Obesity and Diabetes Research at UT Southwestern Medical Center at Dallas. He obtained his BS and MD degrees from the University of Iowa and completed his internal medicine residency, gastroenterology fellowship, and Howard Hughes post-doctoral fellowship at UT Southwestern Medical Center. Dr. Horton is a former PEW scholar and member of the American Society for Clinical Investigation and Association of American Physicians. He serves as a consulting editor for Arteriosclerosis, Thrombosis, and Vascular Biology and as an associate editor of The Journal of Lipid Research.

David Cohen
David Cohen

MD, PhD

Dr. Cohen is a Medical and Scientific Advisory Board member for Gemphire. He is the Chief of the Division of Gastroenterology and Hepatology in the Weill Department of Medicine. A member of the American Society for Clinical Investigation (ASCI) and the Interurban Clinical Club, Dr. Cohen is an internationally renowned physician-scientist with a major interest in the molecular regulation of hepatic lipid and glucose metabolism. Dr. Cohen's research has been funded robustly by the NIH, including the prestigious MERIT Award, and by numerous foundations. The American Association for the Study of Liver Diseases (AASLD) recently announced Dr. Cohen became the editor of Hepatology, the premier journal in the field of hepatology in July 2016.

Rohit Loomba
Rohit Loomba

MD, MHSc

Dr. Loomba is a Medical and Scientific Advisory Board member for Gemphire. He is an expert in the clinical management of chronic liver diseases and holds a joint appointment in the Division of Gastroenterology in the Department of Medicine and the Division of Epidemiology in the Department of Family and Preventive Medicine, University of California at San Diego School of Medicine. Dr. Loomba’s research focuses on all aspects of nonalcoholic fatty liver disease including aging, epidemiology, genetic and environmental predisposition, natural history, and treatment of nonalcoholic steatohepatitis (NASH).

Mechanism
Brian Krause
Brian Krause



Dr. Krause is a Scientific Advisory Board member for Gemphire. He was Co-Founder and Chief Scientific Officer of AlphaCore Pharma, LLC (a cardio orphan drug company sold to MedImmune /AstraZeneca in 2013). Prior to founding Alphacore, Dr. Krause was Head of Research and Senior Vice President at the first Esperion Therapeutics, Inc. He later served as an Executive Director of Discovery at Pfizer Inc.




Gerald Watts
Gerald Watts

DSc MD PhD FRCP FRACP

Dr. Watts is a Medical and Scientific Advisory Board member for Gemphire. Gerald Watts trained at Imperial and King’s Colleges, London University, United Kingdom. He is a senior consultant physician, specializing in cardiometabolic medicine, and current chair of The Familial Hypercholesterolaemia-Australasia Network. He is the clinical lead of Cardiometabolic Services in the Department of Cardiology at Royal Perth Hospital and is Professor of Cardiometabolic Medicine in the University of Western Australia. Research interests include lipid disorders, obesity and cardiovascular prevention, and clinical interest focuses on delivering improved health care for high risk dyslipidemias. He has authored over 500 published works and is on the editorial board of Atherosclerosis, Clinical Science, Metabolism, Journal of Clinical Lipidology, and Current Opinion in Lipidology.

Todd Leff
Todd Leff

PhD

Dr. Leff is a Medical and Scientific Advisory Board member for Gemphire. His research interest is the regulation of gene expression by metabolic and nutritional signals. The laboratory of Dr. Leff is focused on understanding the molecular mechanism that underlie the metabolic diseases of diabetes and obesity, and in deciphering the role that gene expression plays in both the etiology and treatment of these diseases. Specific areas of focus are the molecular biology of two transcription factors whose activity is specifically regulated by metabolic and nutritional signals - the nuclear receptors PPARγ and HNF4α.

Kevin Jon Williams
Kevin Jon Williams

M.D.

Dr. Williams is a Medical and Scientific Advisory Board member for Gemphire. An avid researcher with many published works to his credit, Dr. Williams has performed groundbreaking studies in the areas of lipoproteins, atherosclerosis, and more recently, type 2 diabetes. Examples include the ‘Response-to-Retention’ hypothesis of early atherogenesis, identification of sulfatase-2 as an inhibitor of atherogenic remnant lipoprotein removal by the liver in type 2 diabetes, and discovery of the NSAPP oxide transport chain, which is a key regulator of balanced insulin signaling. Dr. Williams serves on the editorial board of Arteriosclerosis, Thrombosis and Vascular Biology (an American Heart Association journal) and Rambam (Maimonides) Medical Journal.